https://fischerlab.dana-farber.org/

The Fischer Lab at Dana-Farber Cancer Institute is a Structural and Chemical Biology Lab that combines a broad range of laboratory techniques to study the pathways and protein complexes involved in the regulation of protein homeostasis often associated with human diseases, including cancer. Using our knowledge of the cellular degradation machinery, we use structure and computational guided approaches to develop and test new molecules that hijack the ubiquitin proteasome system for targeted protein degradation. Combining fundamental mechanistic insights with translational chemical biology research, we are pioneering new therapeutic avenues.

The Fischer lab (https://fischerlab.dana-farber.org/) seeks a highly motivated individual to join the team as a chemistry Research Technician. This individual will be an important member of our research team and will be centrally involved in assisting various research projects of the Fischer Lab. In addition to the bench-based research, responsibilities will also include some aspects of laboratory management and organization. Training is available in all aspects of experimental research.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

• Assist with the synthesis, purification, and characterization of small molecule inhibitors and degraders.
• Collect, analyze and interpret data and contribute towards plans for follow-up experiments.
• Interact with colleagues within and outside of the Fischer lab to collaborate and advance projects.
• Undertake general laboratory responsibilities such as maintenance of lab equipment and stock reagents and supplies.
• Responsible for maintaining detailed notebook of all work-related activities.
• Compile and analyze experimental data and interpret results to write summaries of findings for presentation of results to staff
• Monitor laboratory work to ensure compliance with Environmental Health and Safety information as well as the standard operation procedures specific to each laboratory.

SUPERVISORY RESPONSIBILITIES:

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Research Technician

No supervisory responsibilities. Normally receives detailed instructions on all work.

• Bachelor's Degree with a major in chemistry required.
• Research experience (>1 yr) in organic chemistry or medicinal chemistry strongly preferred.
• Experience with compound characterization with LC-MS and NMR preferred.
• Experience with using chemistry lab equipment preferred.
• Must be self-motivated and have excellent communication skills (written and verbal).
• Ability to analyze information and use logic to address work-related issues and problems.
• Ability to design synthetic routes and trouble shoot reactions preferred.
• Must have attention to detail and be thorough in completing work tasks.
• Ability to work as part of a multidisciplinary and collaborative team.
• Must have strong time management skills.
• Required one (2) year minimum but can be extended upon mutual agreement.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

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