We are in search of a highly motivated Research Technician to join the Shipp lab at Dana-Farber Cancer Institute. The successful candidate will have a strong interest in cancer biology, immunology, genetics and therapeutics and will function as part of a multidisciplinary basic science and translational team.

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The Research Technician will work closely with our multidisciplinary collaborative group to conduct studies focused on understanding immune evasion in aggressive B-cell lymphomas, with a particular emphasis on classical Hodgkin lymphoma. The Research Technician will participate in studies that involve transcriptomic and proteomic analyses, in vitro co-culture assays of immune recognition and function, development of a novel lymphoma-specific organ-on-a-chip model, new drug screening and complementary genomic analyses, under the supervision of a senior post-doctoral fellow. This role provides a valuable learning opportunity in tumor immunology, cancer biology and genomic analysis, offering exposure to cutting-edge techniques and clinical translation. Additionally, participation in regular group meetings will further enrich the technician's understanding of these areas of investigation.

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The candidate will perform a variety of experiments, such as blood and primary sample processing, DNA/RNA extraction, PCR, lentiviral vector production and transduction, cell culture of cell lines and primary cells, flow cytometry, cell sorting, and in vitro immunologic assays including novel organ-on-a-chip model systems, collaborate in genomic and spatial analyses of tumor specimens and assist in interpretation of results. The candidate will also perform basic laboratory duties, such as maintenance of laboratory instruments and equipment, preparation of solutions, organization of stocks and ordering, and management of the lab biorepository.

We are seeking candidates with at least two years of availability.

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Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

We are seeking a Research Technician to participate in the analyses of genetic and cellular mechanisms of immune evasion and contribute to the identification of associated circulating biomarkers and novel therapeutic targets in aggressive lymphoid malignancies.

• Assist in the preparation and execution of laboratory experiments.
• Isolate immune cells from patient blood and primary samples, and also participate in sample banking activities.
• Support the development and optimization of in vitro co-culture assays of immune evasion and recognition and a novel organ-on-a-chip model.
• Participate in the design and execution of experiments to elucidate cellular and genetic bases of immune evasion.
• Participate in the design and execution of experiments to evaluate the efficacy of candidate compounds in reprogramming immune cell activity.
• Collect, analyze, and interpret data under the supervision of a senior postdoctoral fellow.
• Maintain a detailed notebook and accurate records of experimental procedures and results.
• Keep a clean and orderly work area within the laboratory.
• Maintain equipment and supplies in a neat and orderly manner.
• Prepare reagents, solutions, and samples for experiments.
• Document experimental procedures and results accurately.
• Collaborate with team members to troubleshoot and optimize experimental protocols.

SUPERVISORY RESPONSIBILITIES:

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Research Technician

No supervisory responsibilities. Normally receives detailed instructions on all work.

• Bachelor's or Master’s Degree required with a major in biology, biomedical science, immunology or a related field.
• Experience working in a wet laboratory environment is required, including skills in flow cytometry, cell culture experiments (such as transfection, transduction, cell sorting), and molecular biology assays.
• Experience in blood and primary sample handling, as well as immune cell isolation and purification techniques, is a plus.
• Knowledge of information and techniques related to immunology and molecular biology is preferred.
• Must have excellent attention to detail and be thorough in completing tasks, with strong documentation skills.
• Excellent communication skills are required.
• Must have good time management skills
• Ability to work effectively within a team environment.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

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Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

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